Werner Treptow

Werner has a B.S. degree in Biology (1998), Ph.D in Molecular Biology (University of Brasilia, 2003) and Ph.D. in Theoretical and Computational Chemistry (University Henri Poincaré, 2004). He was a postdoctoral scholar in the laboratory of Prof. Mounir Tarek at the University Henri-Poincaré in France and in the laboratory of Prof. Michael L Klein at the University of Pennsylvania in the US. After his postdoctoral training, he joined the University of Brasilia in Brazil (2009) as an Associate Professor of Computational Molecular Biophysics. Since then, he has worked in the research field of structure, function and regulation of membrane proteins, he has trained graduate students and postdoctoral scholars, in addition to establishing international collaborations as a visiting Professor at the Institute for Computational Molecular Sciences at Temple University (2012-2013) and at the Gordon Center for Integrative Sciences at the University of Chicago (2021-2023). He has extensively worked as a reviewer for scientific journals and more recently, he became an Associate Editor in Frontiers in Cellular Neuroscience.

CV lattes

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Selected Papers

Allosteric modulation of membrane proteins by small low-affinity ligands

Treptow W (2023). J. Chem. Inf. Model..

Concentration-dependent thermodynamic analysis of the partition process of small ligands into proteins

Cirqueira L, Stock L, Treptow W (2022). Comput and Struct Biotech J 20, 4885-4891.

Trivial and nontrivial error sources account for misidentification of protein partners in mutual information approaches

Pontes C, Andrade M, Fiorote J, Treptow W (2021). Sci Rep 11, 6902.

Coevolutive, Evolutive and Stochastic Information in Protein-Protein Interactions

Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins

Stock, L., Hosoume, J., & Treptow, W. (2017). Sci Rep 7, 5734.

Electric fingerprint of voltage sensor domains

Souza, C. S., Amaral, C., & Treptow, W. (2014). PNAS 111, 17510-17515.

Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

Delemotte, L., Tarek, M., Klein, M. L., Amaral, C., & Treptow, W. (2011). PNAS 108, 6109-6114.

Initial Response of the Potassium Channel Voltage Sensor to a Transmembrane Potential

Treptow, W., Tarek, M., & Klein, M. L. (2009). JACS 131, 2107-2109.